Scientists discover unconventional diabetes treatment in Texas.
Diabetes is the disease whereby a human is inability to process the carbohydrates.
A condition that if left untreated could lead to catastrophic health consequences such as lethargy, diminished eyesight, heart attacks, common strokes, sometimes blindness and a loss of blood circulation in the feet that could lead to amputation.
At the University of Texas, health researchers think that they have found a way to trick the body into curing the Type 1 diabetes.
An immune system of a diabetic person kills off useful “beta” cells, while researchers say they have got other options to make other cells in the pancreas perform the necessary work.
Earlier this month, as per their approach, in the academic journal Current Pharmaceutical Biotechnology, would have implications for Type 1, formerly called Juvenile diabetes, and also could help treat the very well known Type 2 variety, also known as Adult-onset diabetes.
Experiments were done on mice by the researchers which are genetically similar to people but different enough that new rounds of animal testing & millions of dollars and more are required before human trials can begin.
The researcher’s approach are sure to receive scrutinism as it is yet another attempt from the many other attempts at curing diabetes, which typically involve transplanting new cells and/or suppressing the immune system’s attempts to kill off the useful ones.
We are actually taking a cell that is in the human body and programme it to secrete insulin, without changing its characters” said Ralph DeFronzo, diabetes researcher at the UT Health Science Center @ San Antonio.
The Centers for Disease Control and Prevention estimated that in the year 2014, about 29 million Americans; 1 in 10 persons had diabetes.
The core problem is insulin. Most people naturally intake that substance when they eat something with carbohydrates, such as bread, potatoes and candy bars.
Insulin acts as an agent that delivers the sugar from the bloodstream into the cells, providing the cells with the energy to function. In most people, the body continuously monitors blood sugar and produces insulin as & when needed.
TYPE 1 and 2 diabetes
In Type Two diabetes, 9 out of 10 diabetes cases and generally associated with the older people and weight gains, the cells reject the insulin, causing sugar to collect and build up in the bloodstream even as cells are starved for energy.
Type Two treated with pills that tell the cells to let in the insulin. But in Type Two diabetes, the body often gradually loses the ability to produce insulin, requiring insulin injections.
In Type 1, the researchers studied that the body has simply stopped producing insulin.
This type is often seen in children, though it can sometimes develop in adults as well.
The People with Type 1 diabetes gain their Insulin from injections, which is an often imprecise task.
Intake of lesser amounts of insulin and blood sugar levels stay high for longer periods potentially damaging the body.
Vice-versa could induce a crash, possibly causing a person with diabetes to faint or experience even worse problems, such as a stroke.
DeFronzo’s partner, Bruno Doiron, decided to check whether the body could reliably produce insulin without the transplantation of new cells.
He used a “gene transfer” technique on mice.
Delivered through a virus, that activated insulin production in cells already in the pancreas, for instance, those that produced certain enzymes.
Fundamentally, we are not changing anything in the cell, we are only handing over an additional task.
The immune systems of mice did not attack the new cells producing insulin.
Very importantly, the cells did produce just the right amount of insulin, not so much that they sent a mouse into a blood sugar free fall, not so little that blood sugar levels stayed high.
The mice have shown no signs of diabetes for more than 12 months now, according to the findings.
Yet, lots of research pending before testing will start on people.
Now, raising enough money as they estimate $5-$10 million.
Later proceed to testing on larger animals, such as pigs, dogs or primates.
The next step that is in discussion with the U.S. Food and Drug Administration.
They hope to start the human trials in three years time.
DeFronzo and Doiron said they do expect skepticism.
Driven by how unconventional their work is.
The established technique used for transfer of gene using virus, approved dozens of times by the FDA to treat diseases.
Doiron also stated-“We can use the cells the body has naturally. “This wakes up the cells to produce insulin.”
Type 1 and Type 2 diabetes dealers
Both these diseases deal with insulin, the substance produced in body that takes sugar from our bloodstream into the cells & power the body.
Type 2 is far more common. The prime issue is that the cells reject insulin, causing sugar to build up in the bloodstream.
The common treatment is the pill that makes the cells accept the insulin (and sugar it carries into the cell). Over a period of time, people body stops producing it.
With Type 1 diabetes, people just stop producing insulin as body kills the cells in pancreas.
Those with Type 1 diabetes must inject or ingest insulin.
People with Type 2 increasingly depending on insulin injections, sometimes can be cured or controlled through diet and exercise.
Mice research diabetes, unconventional diabetes treatment, diabetes alternative treatment, top/famous diabetes researchers, testing for diabetes cost.