Curing type 1 diabetes requires a combination of three strategies. The immune system needs to be reset, its actions need to be regulated, and beta cells need to be regenerated. Joslin is tackling this suite of problems with the 3Rs project, a collaboration between three researchers studying the immune system and beta cells. While his colleagues in the 3R project — Stephan Kissler, Ph.D. and Peng Yi, Ph.D. — are working to regulate the autoimmune system and regenerate the lost beta cells, Dr. Tom Serwold is figuring out how to reset the immune system. This will prevent the autoimmune T cells from being introduced into the system. He s doing that by mounting a targeted attack against the immune cells that are primed to destroy beta cells, and then replacing them with healthy cells.
Type 1 Diabetes (Disease Or Medical Condition),Diabetes Mellitus (Disease Or Medical Condition),Joslin Diabetes Center (Nonprofit Organization)