How conventional Bolivian healers deal with diabetes crisis

 

Bolivia joins hands with traditional healers to help diabetics who are wary of modern medicine.

 

Diabetes is fast emerging into a national crisis in Bolivia.

Nearly half a million Bolivians, some 4.5% of the total population, suffer from the disease & a change of diet is being held responsible.

With many diabetics also not comfortable with modern medicine, the government has teamed up with traditional healers to deal with the growing & imminent health problem.

 

“For me, it’s imperative to incorporate inherited teaching … [patients] can heal with plants & herbs,” said German Mamani, a specialist in conventional remedies.

Find out How conventional Bolivian healers deal with diabetes crisis

Up until the 1980s, conventional medicine was prohibited in Bolivia. Now, the government encourages traditional practitioners to work alongside contemporary medicine to reach those with diabetes, especially in native communities.

Merging both traditional curative practices & current medicine is helping to educate Bolivians on prevention.

 

“Bolivia is a largely an indigenous society & is increasingly using its ancient medicines to deal with a very modern problem,” said Mario Vargas, a Kallawaya, or traditional healer, who practises an ancient type of medicine inherited from his ancestors & adapts it to the modern world.

Find out How conventional Bolivian healers deal with diabetes crisis

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Woman sheds More Than 40 Pounds – to Donate Kidney to a Friend

Find out how this Woman sheds More Than 40 Pounds

 

Rebekah Ceidro, a Pennsylvania woman lost in excess of forty pounds to give her kidney to a longtime

Can Chris Moore can avoid a kidney transplant

friend.

Rebekah Ceidro, aged 33, had worked with her friend Chris Moore, aged 30, for five years at a local eatery and later kept in touch through Facebook.

But in July, when Ceidro saw Moore’s status update post which said he was in need of a kidney, she knew she had to get to the bottom of the matter.

“I thought, ‘Oh my God. This is dreadful,'” Ceidro said. “In my judgment he was always the pinnacle of health and fitness. I thought somebody needs to step up and be of assistance to him and I thought, ‘Well, if I am saying that then I ought to be that individual.'”

Find out how Rebekah Ceidro shed More Than 40 Pounds

After messaging Ceidro, she found out that he was really suffering from kidney failure and she asked what she could do to help. As fate may have it, they realized that they were both O positive blood type.

“So I said, ‘

Find out how this Woman sheds More Than 40 Pounds

Well let me know what you need?’ and, ‘What’s the 1st step in going forward with this?'” Ceidro said. “I said, ‘I’d love to be of help to you if I can. I am fairly sure I have two kidneys that work well and I am happy to part with one of them just for you.'”

In September, Ceidro went for a day of testing and everything appeared to be going well until doctors told her she had to weigh lower than 200 pounds to give a kidney, saying that it may cause complication for her future otherwise.

“I needed to lose eighteen pounds,” Ceidro said. “It’s never uncomplicated to hear somebody say that. I said, ‘I am going to lose the weight then because if that’s all that’s the only bottleneck keeping me from making a life saving difference in my friend’s life, then of course I would do it.'”

And that’s exactly what Ceidro went ahead and did.

She began monitoring her meals on MyFitnessPal and drastically changed her diet. She began running 5 days a week and entering races to get rid of those pounds.

Today, Ceidro weighs a clear 45 pounds. She is set to donate her kidney to Moore in the coming fall.

Can Chris Moore can avoid a kidney transplant

 

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Islet Cell Diabetes Treatment – Cure for all Diabetic Conditions in Sight

Watch the insider report – Islet Cell Diabetes Treatment

The day is not far when doctors will be able to “Cure” Diabetes Patients With A Bio-Engineered Pancreas Implant

Science is always been on the lookout for more sophisticated medical treatments, unfortunately even the most forward thinking methods can have a inadequate effect on genetic conditions. That’s why it’s amazing that scientists are now at the brink of a breakthrough that could in the near future eliminate at least one common medical condition haunting humanity.

Scientists at the University of Miami’s Diabetic Research Institute have managed to bio-hack a diabetic patient’s anatomy in a unique way that she never has to administer an insulin shot ever again.

The undisclosed patient suffers from a variant of Type 1 diabetes, one that’s capable of crippling a person’s lifestyle, thanks to the strict nutritional & medication management it calls for. The researchers transplanted insulin-manufacturing islet cells into the membrane close to her abdomen in order to counter the need for synthetic insulin supplements. Now, almost one year later, the team is delighted to find the surgery is a victory, with the cells still in full working order.

Watch the insider report – Islet Cell Diabetes Treatment

The change of surgery location was also important, as it avoids technical hitches that arise when these cells are implanted, (conventionally) into the liver. The end game now is to spot a suitable position to implant a bioengineered imitation pancreas called the Bio-Hub, that could fabricate insulin to completely offset the patient’s diabetes.

The results are momentous, as the patient says her life prior to the surgery revolved around her condition. “Her quality of life was dramatically impacted,” said the study’s lead author Dr David Baidal told HealthDay. “She had to relocate and live with her parents. And, if she travelled, she had to take the trip with her father.”

If not appropriately treated, diabetes can lead to a variety of further problems, ranging from blindness to nerve damage, & even death. The test’s encouraging results then are a ray of hope to diabetes patients around the globe, who could soon be able to live regular, healthy lives. Instead of relying on a watcher & prescriptions, one simple surgery could render them similar to the next healthy individual, not having to always focus on their medical state.

“We’re looking into a way to optimise islet cell treatment to a larger population,” said Baidal. “This study gives us hope for a radically different transplant approach.”

Watch the insider report – Islet Cell Diabetes Treatment

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 How do I manage my blood glucose level

How do I manage my blood glucose level

 You want to manage your blood glucose levels, here is an app that will help.

For individuals with type 2 diabetes, managing glucose levels can be a daily challenge.

Recently,  introduction of a new algorithm-based app may soon take some of this stress away.

New app

A lot of work pending in the process.

The idea behind the personalized technology is to predict the impact of each meal on a user’s blood sugar levels.

Type 1 and Type 2 diabetes

For a fact, Type 2 diabetes affects upwards of 29 million people in the United States.

Additionally, as a result 86 million adults have prediabetes.

Can develop into type 2 diabetes if lifestyle changes not implemented.

Need for checking our intake of foods to ensure the correct blood glucose levels are maintained. most importantly if levels are too high for prolonged periods of time, serious health complications can arise.

In short, medication is done to help manage sugar level fluctuations, but exercise and diet also play a substantial role.

The impact of specific food types on glucose levels being estimated is not an exact science.

Effects can vary substantially between individuals and they can even vary within an individual dependent on a range of factors.

Research and Findings

A report, published in PLOS Computation Biology explains how a group of scientists have integrated an algorithm into an app called Glucoracle, which goes some way toward solving this problem.

 

In New York, at CUMC, David Albers, Ph.D, lead author of study explains:

“It is tough for people to understand the true impact of the dietary choices even after expert’s guidance.

Albers and team attempt to design an algorithm that can help individuals to make more informed dietary decisions.

App for diabetes

Albers explains how the app works:

“The algorithm as a result is integrated in an easy-to-use app to predict the consequences of eating certain meal before the food is eaten, allowing individuals to make better nutritional choices during mealtime.”

The algorithm used a technique utlized in a range of modern applications.

Includes weather prediction.

Diabetes app workings

The app does data include blood sugar measurements and nutritional information & makes a mathematical model of an individual’s response to glucose on a daily basis.

Lena Mamykina, Ph.D., assistant professor of biomedical informatics at CUMC and a study co-author, explains: “The data assimilator is continually updated with the user’s food intake and blood glucose measurements, personalizing the model for that individual.”

Users of Glucoracle have an option to upload pictures of a meal with rough estimates of nutritional content, along with fingerstick blood measurements.

On the bright side, the app can then almost provide an immediate prediction of post-meal blood sugar levels.

After using app for 1 week

Then it will produce predictions.

This allows the data assimilator to learn how the individual user responds to various types of food. The estimate and forecast adjusts for accuracy over time.

How well does it work?

Overall research carried out on five individuals.

Three had type 2 diabetes and two did not.

Therefore the app predicted changes in glucose levels following a particular meal.

Similarly, we also compared it with the actual glucose measurements.

Best app for type 2 diabetes

Readings quite accurately measured in the non-diabetic participants. 3 people with diabetes, the results turned inaccurate

To begin with, we thought that physiological fluctuations in patients .

Probably due to parameter error, results turned out inaccurate.

Secondly and most important, the predictions were “still comparable” to those of certified diabetes educators.

In contrast, the results are not perfect.

Moreover, Albers is not disheartened. with this in mind, he said:

Certainly, the next step is room for improvement.

The evaluation designed to prove possibility, using routine self-monitoring data, generate real-time glucose forecasts that people could use to make better nutritional choices.

We have made type 2 diabetes manageable easily.

We are trying to better the app.

Plans for larger clinical trial & researchers hope that the app will be ready for widespread use in two years.

To summarize, its all in the making.

There is no doubt, we all will be talking about this rather sooner than later.

Topics included

How do I manage my blood glucose level, manage glucose levels, type 1 diabetes, type 2 diabetes, app for diabetes, mobile phone apps for type 1 diabetes, best app for type 2 diabetes, app for diabetes type 2

How do I manage my blood glucose level

 

 

 

 

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WALK TO DEFEAT DIABETES

Diabetes type 1

Recently, an 11-year-old Florida boy set out to cure diabetes and his family decided to sell their home and everything in it.

 

 

Named Noah Barnes, he has type 1 diabetes diagnosed since he was 16 months old.

He wants to make sure that no child has to go through what he is going through.

The Noah’s March Foundation has raised $15,000 dollars upto now. Noah will march across America in his effort to cure diabetes and spread awareness.

“Forty years ago they said they were pretty close to a cure and then 40 years later….. We still don’t have a cure. Noah Barnes says he is disappointed at this.

Noah got the idea after reading an article online about a diabetes walk fundraiser. He then asked his father– How far do I need to walk so that I can be cured? 

Robert Barnes, the father was not sure of doing the walk and it took about 1 week for Noah to convince him. Noah started training.

Spread awareness diabetes

Now, the whole family is marching from Key West Florida to Washington and it is like a long field trip says Robert.

The three siblings have been on the road for three months. Noah’s brother, 8-year-old John, says it hasn’t been easy. John says he likes the colder places as he does not like to sweat. Noah hopes that others too will support him on this journey.

Noah has worn shoes for this entire journey, and has 3 pairs of shoes. One was for training.

Noah Barnes has a commendable attitude and says “I do not want to quit.” 

On the way, passing through Ashland city, they met few 4th grade children and spoke about diabetes and educated them.

Noah and his family will be passing by Chattanooga on Tuesday afternoon, before they head towards Nashville. They hope to be in Washington by the month of November. Noah and his siblings are homeschooling, while on the road.

 

The kids and us have been enjoying and it is great to meet people and spread awareness. It’s a joy.

 

 

 

 

 

Topics included

Noah Barnes diabetes, diabetes type 1, walk to defeat diabetes, spread awareness diabetes.

WALK TO DEFEAT DIABETES

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Unconventional diabetes treatment

Scientists discover unconventional diabetes treatment in Texas.

 Diabetes is the disease whereby a human is inability to process the carbohydrates.

A condition that if left untreated could lead to catastrophic health consequences such as lethargy, diminished eyesight, heart attacks, common strokes, sometimes blindness and a loss of blood circulation in the feet that could lead to amputation.

At the University of Texas, health researchers think that they have found a way to trick the body into curing the Type 1 diabetes.

An immune system of a diabetic person kills off useful “beta” cells, while researchers say they have got other options to make other cells in the pancreas perform the necessary work.

Approach

Earlier this month, as per their approach, in the academic journal Current Pharmaceutical Biotechnology, would have implications for Type 1, formerly called Juvenile diabetes, and also could help treat the very well known Type 2 variety, also known as Adult-onset diabetes.

Experiments were done on mice by the researchers which are genetically similar to people but different enough that new rounds of animal testing & millions of dollars and more are required before human trials can begin.

The researcher’s approach are sure to receive scrutinism as it is yet another attempt from the many other attempts at curing diabetes, which typically involve transplanting new cells and/or suppressing the immune system’s attempts to kill off the useful ones.

We are actually taking a cell that is in the human body and programme it to secrete insulin, without changing its characters” said Ralph DeFronzo, diabetes researcher at the UT Health Science Center @ San Antonio.

The Centers for Disease Control and Prevention estimated that in the year 2014, about 29 million Americans; 1 in 10 persons had diabetes.

Problems

The core problem is insulin. Most people naturally intake that substance when they eat something with carbohydrates, such as bread, potatoes and candy bars.

Insulin acts as an agent that delivers the sugar from the bloodstream into the cells, providing the cells with the energy to function. In most people, the body continuously monitors blood sugar and produces insulin as & when needed.

TYPE 1 and 2 diabetes

In Type Two diabetes, 9 out of 10 diabetes cases and generally associated with the older people and weight gains, the cells reject the insulin, causing sugar to collect and build up in the bloodstream even as cells are starved for energy.

Type Two treated with pills that tell the cells to let in the insulin. But in Type Two diabetes, the body often gradually loses the ability to produce insulin, requiring insulin injections.

In Type 1, the researchers studied that the body has simply stopped producing insulin.

This type is often seen in children, though it can sometimes develop in adults as well.

The People with Type 1 diabetes gain their Insulin from injections, which is an often imprecise task.

Quantities

Intake of lesser amounts of insulin and blood sugar levels stay high for longer periods potentially damaging the body.

Vice-versa could induce a crash, possibly causing a person with diabetes to faint or experience even worse problems, such as a stroke.

DeFronzo’s partner, Bruno Doiron, decided to check whether the body could reliably produce insulin without the transplantation of new cells.

He used a “gene transfer” technique on mice.

Delivered through a virus, that activated insulin production in cells already in the pancreas, for instance, those that produced certain enzymes.

Fundamentally, we are not changing anything in the cell, we are only handing over an additional task.

The immune systems of mice did not attack the new cells producing insulin.

Very importantly, the cells did produce just the right amount of insulin, not so much that they sent a mouse into a blood sugar free fall, not so little that blood sugar levels stayed high.

The mice have shown no signs of diabetes for more than 12 months now, according to the findings.

Yet, lots of research pending before testing will start on people.

Now, raising enough money as they estimate $5-$10 million.

Later proceed to testing on larger animals, such as pigs, dogs or primates.

The next step that is in discussion with the U.S. Food and Drug Administration.

They hope to start the human trials in three years time.

Famous researchers

DeFronzo and Doiron said they do expect skepticism.

Driven by how unconventional their work is.

The established technique used for transfer of gene using virus, approved dozens of times by the FDA to treat diseases.

Doiron also stated-“We can use the cells the body has naturally. “This wakes up the cells to produce insulin.”

Type 1 and Type 2 diabetes dealers

Both these diseases deal with insulin, the substance produced in body that takes sugar from our bloodstream into the cells & power the body.

Type 2 is far more common. The prime issue is that the cells reject insulin, causing sugar to build up in the bloodstream.

The common treatment is the pill that makes the cells accept the insulin (and sugar it carries into the cell). Over a period of time, people body stops producing it.

With Type 1 diabetes, people just stop producing insulin as body kills the cells in pancreas.

Those with Type 1 diabetes must inject or ingest insulin.

People with Type 2 increasingly depending on insulin injections, sometimes can be cured or controlled through diet and exercise.

 

 

Topics included

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Unconventional diabetes treatment




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Experimental research on effect of temperature on diabetics

Can the temperature make a difference?

Yes, by lowering the central heating temperature by a mere 1 degree Centigrade, it could ease the effects of type 2 diabetes- according to a new study.

Cool temperature eases diabetics

Dutch researchers clearly believe that, if we expose people with the type 2 diabetes to slightly cooler climate then,

Indeed it could increase insulin sensitivity by more than forty percent.

Further, this research could also help in further research on obesity and methods to tackle it.

Professor Wouter van Marken Lichtenbelt- lead author says-

“It was previously assumed that stable &fixed indoor temperatures could satisfy comfort level and health in most humans”
As per research

It indicates that mild cold and variable temperatures could well be having a very positive effect on the health of diabetics.

Mild cold and warm environments will increase metabolism, resulting in targeting obesity by counterbalancing excess energy intake.

As per survey, participants with type 2 diabetes exposed to intermittent mild cold.

Did you know, it increased their insulin sensitivity by Forty percent.

Positive Effect of Cold Temperature on Diabetics -Can it cure the condition?

Overall, the heart health no doubt positively affected by regular exposure to heat as well and cold.

For a matter of fact, few authors also feel that in homes and offices, the adjustment in thermostat could significantly have positive effects on our health.

In 2014, the same team discovered that the colder temperatures were helping to tackle obesity.

Cold temperature increases metabolism

One of the latest study shows that when we are exposed to cooler temperatures, we tend to quickly adapt to situations & end up feeling less tired and have more energy to keep going.

Notably when possible we must try exercising to maintain the body.

In a short interview, speaking to Richard Lorch (editor in chief of the journal) says

“This ground-breaking research gives a new approach to how we look at the heating and cooling of our buildings.

To conclude, our expectations and comfort levels affected by temperature, who would have thought?

Topics included

Cold temperature increases metabolism, cool temperature eases diabetics, increased energy with right temperature, experimental research on effect of temperature on diabetics

Positive Effect of Cold Temperature on Diabetics -Can it cure the condition?




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Chillies for diabetes

Chilli for diabetes is because when we eat chilli, it interacts with the same receptor in our stomachs.

The result is that it help calm the gut, scientists at the University of Connecticut found.

During experimentation with Mice, they were fed both chilli peppers and the class B drug showed less inflammation in their guts.

Chilli peppers cure diabetes

Also, the researchers even found that they were able to reverse type 1 diabetes in some mice, by feeding them the fiery pepper.

The chilli seemed to bind itself to a receptor called TRPV1, which is found in the gut, oesophagus and pancreas.

When it binds itself to the receptor, it creates a compound called as Anandamide, which is chemically quite similar to Cannabinoids found in Marijuana.

 

Reduce inflamed pancreas

It was this compound that caused the immune system of these mice to calm down, by reducing the inflammation, and the same happened when they were fed anandamide directly.

Reducing the inflammation in the pancreas could help in the treatment of diabetes.

As the pancreas is responsible for the maintenance of insulin and glucose levels in the body.

Reason-A diabetes patient has too much glucose in their system and the pancreas is unable to regulate it.

Chillies for diabetes

The brain even creates anandamides when, the receptors in our brain react to people getting high.

Scientists have been unsuccessful to find out why those receptors existed in the past.

Pramod Srivastava, professor of immunology and medicine at the university, said:

“This allows you to imagine how the immune system and the brain might talk to each other as they share a common language.”

Chilli benefits to the body

Additionally, chillies also help in losing weight, boost immunity, and also acts as a natural pain relief

 

Topics included

Chillies for diabetes, chilli peppers cure diabetes, chilli benefits to the body, reduce inflamed pancreas

 

Chillies for diabetes




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Diabetes in kids

 

We all know that Diabetes is a growing problem in our kids.

Fact: Every year 25000 children diagnosed with diabetes.

To start, there are 2 different types of childhood diabetes namely Type 1 & Type 2.

Type 1 diabetes was initially called Juvenile Onset diabetes & is typically diagnosed in children and adolescents. Only five percent of those with diabetes have Type 1.

Our parents worry thinking that their kids will get diabetes as they eat a lot of sugar. Sugar does not directly cause type 1 diabetes.

Type 1 diabetes is an autoimmune disease where our immune system attacks and destroys the beta cells (insulin producing cells) of the pancreas. Scientists are not quite sure why it occurs, but it seems to be a combination of genetic & environmental factors, & has no relation with diet.

Symptoms of juvenile type 1 diabetes

The Type 1 diabetes comes very suddenly and it depends on insulin for the rest of the child’s life.

  • Extreme thirst
  • Frequent urination (day and night)
  • Increased appetite &
  • Sudden weight loss.

Children who develop type 1 diabetes appear to be tired, thin & sick. Parents worry that their child is diabetic because the child drinks a lot of water though this is not the only symptom.

Luckily, the manner in which insulin is given now days continue to improve & most children now use an insulin pump, which delivers insulin in a consistent manner than earlier methods. Even after hopes of pancreas transplants and all, parents find it difficult to manage.

Children’s diabetes type 2

Type 2 diabetes, earlier called “Non-insulin dependent diabetes,” is quite different than before. Earlier diagnosed in adults, currently it is now rising in children too.

In type 2 diabetes, our body is unable to use insulin in the correct way and the glucose in the blood stream is unable to enter the cells. This is called insulin resistance. Hence, the pancreas tries to produce even more insulin to keep blood sugar levels normal. Over time, the pancreas may wear out completely. Type 2 diabetes can be controlled with an oral medication instead of insulin.

Type 2 diabetes occurs in those children who are

  • Overweight
  • Less active &
  • Often have a parent with diabetes

The more children in this country developed obesity, the more the number of cases of type 2 diabetes will continue to rise. In most cases, if a child changes their lifestyle starts a healthy diet, loses weight and importantly exercising, then the body may be able to restore normal insulin balance.

This is the big difference between the type 1 & type 2.

If any concerns for your child, child is showing any signs of diabetes, make sure to consult your doctor. Also, promote healthy eating habits and daily exercise.

Topics included

Diabetes in kids, children’s diabetes type 1, children’s diabetes type 2, symptoms of juvenile type 1 diabetes, diabetes children’s health

 

Diabetes in kids

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Clinical control of diabetes by artificial pancreas

 

Could anyone believe that artificial organs could just be the norm where scientific research is considered?

Well, the University of Virginia has successfully developed also done a trial on the artificial pancreas to help children control Type 1 diabetes.

This could well be a major breakthrough in scientific research that will send shock waves throughout the community moving ahead.

 

 

Research on artificial pancreas

Tangible and feasible solutions research done by scientists from all over the world to fight diabetes. Unfortunately, to no effect.

Though recently, there seems to be a small light at the far end of this long tunnel in recent times.

Yes, the University of Virginia has developed an artificial pancreas that will surely help young children to control their Type 1 diabetes.

 

Evaluation

Though on paper, creating an artificial pancreas would sound like something worth checking out.

There is never a guarantee for success.

 

Workings

What this “organ” does is that it actively monitors & regulates the blood-sugar levels of its host.

This removes the need of manual injections of insulin nor do we need to prick our fingers to check blood sugar levels.

As advertised, this artificial pancreas is significant for the medical sector as a whole.

 

Latest research on artificial pancreas

With technology,

All data gathered by artificial pancreas sent to a reconfigured smart phone.

It will run algorithms to process the data.

The smart phone then forwards the information to a blood-sugar monitor & insulin pump worn by the person suffering from Type 1 diabetes.

Additionally, all information simultaneously broadcast to a remote monitoring site.

On patient behalf, data collected

Another huge benefit to this artificial pancreas is that it can also prevent hypoglycemic events, which is 1 of the bigger concern for children with Type 1 diabetes.

 

Trials

Conduction of a field trial among twelve children and all were perfectly capable to control their diabetes using the new method.

 

Results good

Noticing, children wearing the artificial pancreas had lower average blood-sugar levels.

No increment in hypoglycemia during trial

This was designed for children between the age of five & eight.

And it differs from technology devised to support other age categories in upcoming future.

For the time-being, the plan is to monitor children for extended period of time and check whether the artificial pancreas is as effective at school as well.

 

Experimental artificial pancreas

Conducted first test during a 68-hour window both with and without the pancreas.

This only gives a glimpse of how this “organ” could hold up.

Further plans are to provide an artificial pancreas to children aged 14+ & suffering from Type 1 diabetes.

Topics included

Clinical control of diabetes by artificial pancreas, research on artificial pancreas, latest research on the artificial pancreas, experimental artificial pancreas

Clinical control of diabetes by artificial pancreas

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Can Synthetic Biology Finally Cure Diabetes?

The Type 1 diabetes is one of the most discouraging disease.


Although we have the availability of synthetic insulin and increasingly sophisticated monitoring technology, it is yet a condition that requires incessant vigilance. The diabetics must constantly track their blood sugar levels and re-evaluate their drug dosage. None the less, despite the management, bad days remain almost inevitable. If we intake large amount of insulin, and you can spiral into a hypoglycemic delirium. Take lesser & your glucose levels will rise, filling the body with dangerous levels of Ketones.

Whats come up recently?
Possible cures routinely come up only to fade from view, their benefits just fall short of the simple efficacy of an Insulin injection. Recently, though, in the field of synthetic biology—a hybrid discipline that aims to construct or redesign biological components and systems—has shown the potential to produce a number of treatments. The solutions remain speculative, but hope is all we look out for during such phases.


John Glass, A researcher working on one such new effort, knows how false hope can be maddening, having lived with the disease for decades. Type 1 diabetes, in theory, is quite easy to solve, not practically, he said. All said than done, he still takes insulin daily.
There are ways to re-engineer the genomes of skin bacteria in ways that would allow to execute functions that the diabetic’s bodies no longer can. Whether or not that ultimately works, synthetic biology will continue to provide ways around problems that have long been insurmountable for researchers.
Glass, Explains the Type 1 diabeties; At core, It is an Auto-immune disease, one that results from a biological glitch that leads the body to attack the insulin-producing beta cells of its own pancreas. Beta cells serve 2 primary functions in a healthy organism.
• They detect blood glucose levels within the body.
• When those levels begin to rise, the cells secrete insulin. The autoimmune kills off the beta cells, leaving the body with no way to process the carbohydrates it consumes.
Finally, the researchers behind this sought to re-engineer human embryonic kidney cells to copy the functions of the pancreatic beta cells that immune systems of those with diabetes destroy. These new cells were injected into diabetic mice, resulting in a success.

Can Synthetic Biology Finally Cure Diabetes?
It is the autonomous, or “closed loop,” quality that’s most exciting here that offers the potential to stabilize the body without the regular injections and blood sugar checks. True closed-loops recreate the healthy body through natural processes, just like these modified kidney cells that automatically distributes insulin in response to blood sugar fluctuations. Such systems have long been the holy grail for diabetic researchers.
Medical technologists too have been working long on devices that would achieve similar results by more mechanical means. MedTronic (recently received FDA approval) for what it calls a “closed loop” combination of a digital glucose sensor and an insulin pump that it has plans to roll out later this year. It can be a game-changing device, but it still demands involvement from the user, who must feed it the required information about the carbohydrate intake, regularly recalibrate the sensor & attach the sensors and insulin pump to their body. By comparison, synthetic biology promises to be a truly hands-off solution.

Problems
The diabetic body’s seemingly irreversible autoimmune response is the bane because the mimetic replacements resemble the natural beta cells, hence the immune system still recognizes them as targets and eventually kills them off. Although they work under experimental conditions for a few weeks, their effectiveness fades with time, as Glass and other researchers explained. “We yet do not know how to overcome that hurdle”

Chad Cowan, director of the diabetes program at the Harvard Stem Cell Institute, told us that the issue has been extremely difficult to resolve.
 “Over the course of the last two years, we’ve … tried to talk to every immunologist and every person who works on autoimmunity, particularly if they have any focus on type 1 diabetes,” he said.
 “Our overall assessment is that there isn’t an easy solution, at least in terms of modulating the immune system.”
It’s here that the real promise of Glass’ proposal reveals itself. He thinks he’s found a solution for the problem that would allow the body to autonomously produce insulin as needed & without risk of disruption.

Glass thoughts
Glass’s own professional involvement in the field began a few years ago when he met Alberto Hayek, a diabetes researcher and emeritus professor from University of California–San Diego.
Hayek introduced Glass to the work of a dermatologist named Richard Gallo, who discovered a beneficial bacteria living deep in the layers of our skin that seem to be overlooked by the immune system.

Would it be right to harvest and modify these microbes so that they function like Instead of making new beta cells that will face rejection ,they rather take something that the body still accepts and make it to act like a beta cell.
It seemed very feasible to Glass. Also, he might be able to “take those cells from any given person & put in the machinery beta cells?
that would allow those cells now to sense blood glucose, there in and amongst the capillaries that are in our skin.” And since the immune system usually passes over these particular microbes, it might just let the newly engineered cells go about their business. Further, We also know that if you put bacteria on your skin, they very quickly make it into the deep layers, meaning it could potentially be delivered via a nonintrusive application, such as personalized skin cream.
Glass’s work is still in its initial stage. He along with colleagues at JCVI are seeking funding to conduct experiments in mice.

Topics dicussed
Type 1 diabetes,re-engineer of human kidney cells, scientific, synthetic biology,track blood sugar, Can Synthetic Biology Finally Cure Diabetes

Can Synthetic Biology Finally Cure Diabetes?




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